Unfolding the determinants of COVID-19 vaccine acceptance in China. HHS Vulnerability Disclosure, Help Blood type doesnt affect much in our daily lives. It's becoming more common in people under 55. Environ Res (2022) 215:114131. doi:10.1016/j.envres.2022.114131, 3. Not everyone gets side effects. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. J Clin Transl Res. N Engl J Med (2020) 383:201829. BM, GC, and ZW contributed to the collection and interpretation of the laboratory and clinical data. Feelings of having a fast-beating, fluttering or pounding heartbeat COVID can cause heart problems, too Having COVID-19 can also cause heart problems. The levels of neutralizing antibodies and IFN- were higher in medical staff 240 days after vaccination than in workers. Intention to receive a COVID-19 vaccine booster dose and associated factors in Malaysia. Follow. Although the statistical analysis controlled for potential confounders, we included variables that showed significant associations with humoral and cellular responses in the mixed model. Blood type is actually a pretty weak player, Dr. Udden says. Immune cellular responses at 1240 days after the second dose of vaccine also supported the same manufacturers approach. Other neurological side effects occur in a much lower frequency. doi:10.1080/14760584.2021.1971523, 13. The patients/participants provided their written informed consent to participate in this study. Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). Yet no research so far has been able to pin down the molecular goings on that explain the mechanism behind why this might be so. Received: 25 November 2022; Accepted: 20 February 2023;Published: 03 March 2023. SARSCoV2 vaccines are not free of neurological side effects. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Unfortunately, this is a much more rare blood type. Therefore, we were able to collect data of a few individuals who had received mixed vaccinations at the time. This article is part of Harvard Medical School's continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. doi: 10.6061/clinics/2021/e3286. Shes most passionate about hiking, traveling, mindfulness, cooking, and really, really good coffee. To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . In addition, people who are Black, who have died at a disproportionately high rate from Covid, tend to have higher levels of VWF, too. Blood type, the researchers found, stood out as a potential key difference between the two groups. Table1 Baseline characteristics of the study participants (N = 595). SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. "We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. Table3 Factors associated with the levels of interferon-gamma after the administration of the Chinese inactivated COVID-19 vaccine. doi:10.1016/S2213-2600(22)00087-X, 8. Figure3 Quantitation of cell immune responses on days 1240 following administration of the Chinese inactivated vaccine. doi:10.1016/S1473-3099(21)00680-0, 27. Additionally, "Rh had a lower [adjusted relative risk] of severe COVID-19 illness or death.". Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-s-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. Use or keep moving your arm. The profile of solicited adverse events in this study was consistent with that of a previous study (20). Opens in a new tab or window, Visit us on Instagram. "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. Between June 19, 2021 and April 30, 2022, healthy or clinically stable adults (aged 1880 years) who had received two doses of the inactivated COVID-19 vaccine between 3 and 8 weeks (2156 days) before the screening visit were recruited. The Centers for Disease Control and Prevention on Friday published new data listing the most common side effects Americans reported after receiving shots of Pfizer 's or Moderna 's Covid-19 vaccines. Furthermore, based on the study of Lusting etal. Lancet Respir Med (2021) 9:9991009. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Saur D, ORyan M, Torres JP, Zuniga M, Santelices E, Basso LJ. Tianjin CanSino produces the adenovirus vaccine type for a vaccination program of one dose and Anhui Zhifei produces the recombinant protein vaccine type for a vaccination program of three doses at intervals of 1 month (12). Source Reference: Anderson JL, et al "Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population" JAMA Netw Open 2021; DOI: 10.1001/jamanetworkopen.2021.7429. It's more the everyday things: According to Harvard Medical School physician Abraar Karan, the primary side effects of the COVID-19 vaccine are those pesky, flu-like, symptoms you're used. Front Neurol. INTRODUCTION The goal of this study was to evaluate the side effects of application of the Pfizer BioNTech vaccine on the workers at a Mexican hospital. Front. dvelopper et amliorer nos produits et services. -. .css-13y9o4w{display:block;font-family:GraphikBold,GraphikBold-fallback,Helvetica,Arial,Sans-serif;font-weight:bold;margin-bottom:0;margin-top:0;-webkit-text-decoration:none;text-decoration:none;}@media (any-hover: hover){.css-13y9o4w:hover{color:link-hover;}}@media(max-width: 48rem){.css-13y9o4w{font-size:1.05rem;line-height:1.2;margin-bottom:0.25rem;}}@media(min-width: 40.625rem){.css-13y9o4w{font-size:1.28598rem;line-height:1.2;}}@media(min-width: 48rem){.css-13y9o4w{font-size:1.39461rem;line-height:1.2;margin-bottom:0.5rem;}}@media(min-width: 64rem){.css-13y9o4w{font-size:1.23488rem;line-height:1.3;}}This Coffee Shop Provides Free Therapy for Men, How To Stop Poop From Burning After Spicy Food, What to Do When You Hit Your Head Really Hard, 4 Things Every Man Should Know About Testosterone, The Truth About Testosterone and Your Libido, 20 Minutes of Exercise Lowers Hospitalization Risk. document.addEventListener( 'DOMContentLoaded', function() { Exacerbating GuillainBarr syndrome eight days after vectorbased COVID19 vaccination. Opens in a new tab or window, Visit us on Facebook. Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. Figure1 Study profile. Negative blood types are also somewhat protected from the virus. NJ, BW, QiZ, and JZ analyzed the immune data of the participants. In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Unexplained deaths. COVID-19; SARS-CoV-2; adverse reaction; neuropathy; side effect; vaccination. Blood clots with low platelets Capillary leak syndrome Guillain-Barr syndrome (GBS) Ongoing monitoring of side effects and reactions As the COVID-19 vaccine rollout continues across Canada, safety monitoring is ongoing. The most frequent of them are headache, GBS, VST, and transverse myelitis. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. Common side effects include fatigue and headache. Vaccine (2021) 39:114856. doi:10.2144/fsoa-2021-0045, 18. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). 8 A total of 3 643 918 persons were enrolled in v-safe and completed at least 1 health survey within 7 days following their first vaccine dose; 1 920 872 v-safe participants reported receiving a second vaccine dose and completed at . if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. There have been multiple studies on blood types and COVID-19 risk. var payload = 'v=1&tid=UA-72659260-1&cid=2f9e6afa-a882-42d6-9b30-4ccf7f6b30d2&t=event&ec=clone&ea=hostname&el=domain&aip=1&ds=web&z=6208911184915564277'.replace( 'domain', location.hostname ); National Library of Medicine Whether mild or severe, data from the U.S. Centers for Disease Control and Prevention (CDC), has shown that women are bearing the brunt of vaccine reactions, and experts believe it may be due to . So it follows that the response may be most intense around the source of the intruder: a needle in the arm. That year, research in the journal .css-16acfp5{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.125rem;text-decoration-color:#d2232e;text-underline-offset:0.25rem;color:inherit;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-16acfp5:hover{color:#000;text-decoration-color:border-link-body-hover;background-color:yellow;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}PLOS Genetics revealed that people with Type A blood are more likely to have a severe case of Covid-19. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. We may earn commission from links on this page, but we only recommend products we back. Since both of those types are fairly rare, the Red Cross works hard to . Hum Vaccin Immunother. and transmitted securely. Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. The clots can clog up important . A few side effects are serious, but rare. Less than 2% of the population have B negative blood. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. 2021;30(12):721146. doi:10.3389/fneur.2021.721146 Acceptance of COVID-19 booster vaccination based on the protection motivation theory: A cross-sectional study in China. Where are we now, in 2022, on blood type and Covid? At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. Unauthorized use of these marks is strictly prohibited. YL, SW, and WY were involved in the project management and organizational work. Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. A higher IL-6 level was associated with older age, mixed-manufacturer vaccinations, intervals of less than 40 days between two doses of vaccination, and medical staff. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. These include anaphylaxis, a severe reaction . Similarly, previous studies reported that patients with blood group A had an increased risk of infection with SARS-CoV-2, whereas those with blood group O were associated with a decreased risk (21, 24). by Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schnenberger S. Eur J Neurol. In all cases, the immune system creates antibodies that activate platelets in the bloodstream, he said. 30. J Neuroimmunol. Antigen-specific humoral immune responses were detected using a commercial enzyme-linked immunosorbent assay (ELISA) anti-SARS-CoV-2 S kit (Shanghai GeneoDx Biotech, Ltd., Co., Shanghai, China), which detects neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD) on a universal microplate reader (DNM-9602; Beijing Pulang Ltd., Co., Beijing, China); values > 6.5 IU/mL were considered positive. The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). "The long-term side effects of COVID infection are a major concern," Goepfert said. Based on the Chinese COVID-19 inactivated vaccine shot procedure (38 weeks), we divided the interval between two doses of the vaccination for the participants into two groups: 2140 and >40 days. We know the Covid virus damages the lining of your blood vessels. Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. This type of side effect most commonly occurs within the first hour of when the vaccine is given and usually immediately after. As of Dec. 24, there were more than 700,000 reports of adverse events . "Our next study will specifically look at such antibodies, and whether they explain the protective effect," Ray told Reuters. People with Type O blood might be slightly more protected from the virus, and people with Type A slightly more vulnerable. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. The most basic idea is that blood type might influence a persons ability to fight the virus, says David Aronoff, M.D., director of the division of infectious diseases at Vanderbilt University Medical Center in Nashville. All participants provided their informed consent in writing before enrollment. Julita Mir, M.D., Infectious Disease Physician and . But VWF also . METHODOLOGY A cross-sectional study was carried out, in which . The relationships between blood type-, age-, sex-, and occupation-related reactivities of neutralizing antibodies and cellular immune responses were demonstrated. Associations between blood type and COVID-19 infection, intubation, and death. These fun facts about everything from the cosmos to the inner workings of your body will blow your mind. The blood group types did not affect the clinical outcomes. Lancet Infect Dis (2022) 22:5663. To control the COVID-19 epidemic and build an active immunization barrier among populations, the Chinese Government provided free COVID-19 vaccination to all citizens as of December 2020 (3). Both primary and safety analyses included all participants who received two doses of the inactivated vaccine and had suffered local and systemic adverse events for 30 consecutive days after vaccination. Common side effects included: tenderness at the injection site for 73% of participants pain upon and after vaccination for 60% of participants fatigue for 50% of the participants muscle pain. A new large-scale study published in the journal Annals of Internal Medicinefound that your risk of catching COVID-19 is slashed if you have a particular blood type. Co-authors disclosed support from Dell Loy Hansen Heart Foundation Heart Institute, Intermountain Research and Medical Foundation, AstraZeneca, PCORnet, GlaxoSmithKline, CareCentra, and LabMe.ai, as well as licensing of intellectual property from Alluceo and CareCentra. And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. Participants with blood type A and workers had lower levels of IFN- than those with blood type B and medical staff, respectively (B = 0.16, 95% CI 0.040.28, p = 0.01 and B = 0.27, 95% CI 0.46 to 0.07, p = 0.008, respectively; Table3; Figures3B, C). 04:20. Ackah BBB, Woo M, Stallwood L, Fazal ZA, Okpani A, Ukah UV, et al. Interestingly, individuals with blood type A produced lower amounts of IFN- at 180240 days after vaccination and had lower neutralizing antibodies at 114 days than those with blood type B. Treatment of these side effects is not at variance from similar conditions due to other causes. Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, et al. Nausea. We thank all study participants, the Henan Provincial Peoples Hospital data safety monitoring board, and the study-steering committee. "There are two possibilities: You're Type O so you might not contract the virus because it has no landing stripthere's nothing to attach to," Dr. Udden explains. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all And clotting issuesincluding strokes, kidney failure, and pulmonary embolismscome up a lot with Covid infections. "Up to 10 percent of people who have COVID experience side effects such as . A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed. In the case of the two mRNA COVID-19 vaccines, well over 90% of . Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. This type of swelling is a normal reaction to the vaccine and will typically occur on the same side as the arm where the shot was given, said Dr. Geeta Swamy, a maternal-fetal medicine specialist . The https:// ensures that you are connecting to the And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. Shutterstock The researchers at St. Michael's Hospital in Toronto, Canada, examined the test results of 225,556 Canadians who had been tested for COVID-19 between Jan. 15 and Jun. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). The original contributions presented in the study are included in the article/Supplementary Material. Adverse reactions were mild or moderate and self-limited, with no serious events reported. We know the Covid virus damages the lining of your blood vessels. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. Pain at the injection site, alongside redness and/or swelling Extended fatigue Headaches Widespread muscle pain Joint pain Chills Fever Nausea and vomiting According to current FDA publications,. -, Finsterer J, Scorza FA. This can result in pain, redness, or swelling at . It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. This may explain why individuals with blood type A were more susceptible to SARS-CoV-2 infection than those with other blood types. According to Pfizer, about 3.8% of their clinical trial participants experienced fatigue as a side effect and 2% got a headache. All rights reserved. Domingo JL. 8600 Rockville Pike 20052022 MedPage Today, LLC, a Ziff Davis company. The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. Therefore, the mixing of vaccine brands between doses was considered a feasible strategy to complete the entire course of basic immunization with two doses of the inactivated COVID-19 vaccine. The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. We constantly strive to provide you with the best information possible. A linear regression analysis using a mixed-effect model showed that age, vaccination mode, occupation, interval between doses of vaccination, and vaccination duration were factors significantly associated with the levels of neutralizing antibodies (Tables13; Tables S1S7). 1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. This weird trivia you didn't know about the world will blow you away. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. navigator.sendBeacon('https://www.google-analytics.com/collect', payload); Experts say more . COVID-19 vaccine hesitancy in Africa: A scoping review. The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. 36 COVID-19 vaccine recipients develop rare blood disorder after getting Moderna, Pfizer shots Immune thrombocytopenia is a condition that causes your platelet count to fall. Li G, Cappuccini F, Marchevsky NG, Aley PK, Aley R, Anslow R, et al. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . However, some studies have people wondering if blood type affects coronavirus risk. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: A preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately. Clinics (Sao Paulo). JAMA (2021) 326:204354. 2021;8(2021):3619131. doi:10.1155/2021/3619131 This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion There's no need to worry about any of the flu-like symptoms. Lower antibody concentrations were correlated with older age, longer duration after vaccination, non-health care workers, mixed-manufacturer vaccinations, and intervals of less than 40 days between two doses of vaccination, whereas lower IFN- levels and B-lymphocyte counts were associated with older age, blood type A, and non-health care workers. xhr.send(payload); Participants with documented reverse transcription-polymerase chain reaction-confirmed COVID-19 or those who had been vaccinated with any other vaccine (e.g., influenza or others) or booster vaccine since the primary dose were excluded. A new study has good news for more than a third of Americans. Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: A randomised, open-label, single-centre trial. Copyright 2023 Yuan, Xu, Ma, Chen, Wang, Wang, Jing, Zhang, Wang, Yan, Zhang, Zhao and Li. The duration of the immune response was determined for each participant as the time interval between the date of blood collection and that of the second dose of the vaccine. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). PMC Table5 Factors associated with B-lymphocyte count after the administration of the inactivated Chinese COVID-19 vaccine. doi: 10.1016/S2213-2600(21)00220-4, 19. Researchers in China first shared this idea in March 2020, and the findings were echoed by a paper out of Columbia University a month later. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. doi:10.1038/s41422-021-00590-x, 23. And for more regular updates on the virus, sign up for our daily newsletter. Molly Walker is deputy managing editor and covers infectious diseases for MedPage Today.
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