Effectiveness of dentifrices with new formulations for the treatment of dentin hypersensitivitya meta-analysis. Colgate Total with stannous fluoride also offers more benefits than ever before, including sensitivity relief, improved enamel strength* and odor neutralization* (*based on in vitro studies).Colgate Total Advanced Whitening is a tooth whitening toothpaste that provides stain removal and prevention. Treatments provided to the patients were OTC dentifrices marketed with the claim of immediate pain relief in DH. Pro-Argin Technology works through a natural process of dentin tubule occlusion that attracts arginine and calcium carbonate to the dentin surface to form a protective seal that provides instant relief.2 Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. YYYY Colgate-Palmolive Company. Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: a randomized controlled clinical trial. 5 Hines D et al. 2018. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. volume21, Articlenumber:498 (2021) J Dent. Int J Dent. Colgate Sensitive Pro Relief Whitening Toothpaste 75ml tube (Pack of 4) Instant and Lasting Relief Clinically Proven with Active Ingredients We have a surprise for you Find out all personalised promo codes that you are eligible for. [10] examined the evidence for strontium acetate and Pro-argin in 2018, and their findings depicted low quality of evidence for strontium acetate on the Grading of Recommendations, Assessment, Development, and Evaluations system (GRADE). In addition, participants were asked to record the overall sensitivity of their day-to-day experience on provided VAS sheets reporting pain on brushing, taking hot or cold beverages, and rinsing with tap water for the six weeks of the study. Another study by Hines et al. Hines D, Rinaudi L, Xu S, Lavender S, Pilch S: The Use of Confocal Laser Scanning Microscopy and a Novel Imaging Program for Quantifying Dentine Tubule Occlusion. [16] in a systematic review in 2015. Follow the directions for use. The clinical significance of this study can be highlighted by the fact that this was a person-centred clinical trial where patients were the prime focus where thepatients suffering from DH. Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. observed a significantly greater reduction in sensitivity from air and tactile stimuli when compared to a potassium ion toothpaste, an effect sustained at two, four and eight weeks of use. Instant relief when applied directly to the sensitive tooth with the fingertip and gently massaged for 1 minute. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. Colgate Sensitive PRO-Relief provides you relief from sudden shocks of pain and long-term sensitivity with regular use. Shrimathi S. Effect of BiominF, NovaminR, Argin and nanohydroxy particles containing dentifrices on dentine hypersensitivity and gingivitis among 3544 years aged population of Madurai district: a randomized controlled trial (RCT). in 2018 [17]. Fordeler Colgate SENSITIVE INSTANT Relief tannkrem er klinisk dokumentert virke i lpet av sekunder samtidig som den beskytter tannen mot at smerten skal komme tilbake. 2013;41(2):18794. We observed the varying treatment response at different efficacy intervals that could be due to the varying degree of patient's response to pain-provoking stimuli in DH. It is clinically proven for instant and lasting Sensitivity relief* How does it work? The dropouts of the participants at each efficacy interval may be considered the weakness of this trial that was due to COVID-19 lockdown. . KruskalWallis test was used to compare treatment groups. Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. [8] that demonstrated the inherent ability of chemical interaction between arginine and type 1 collagen molecules in the salivary alkaline PH, thus resulting in endogenous calcium phosphate deposition on exposed dentinal tubules. WAF has contributed to revising the manuscript critically and contributed to statistical analyses. J Evid Based Dent Pract. Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. They explored greater tubular occlusion potential and more acid resistance of Pro-argin in comparison to FCPS after subsequent seven days of application on dentinal discs [38]. [12] suggested a novel BAG component of fluoro-calcium phospho-silicate (FCPS)-containing OTC dentifrice, with the potential of fluorapatite-like crystals formation in dentin in 2017. Indian J Dent Sci. Lasting relief with 2x daily continued brushing. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth**. Statistical Package for the Social Sciences software v.21.0. Children 6 years and younger: use a pea-sized amount for supervised tooth brushing to minimise swallowing. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. In addition, they were responding to air-blast stimulus on the Schiff cold air sensitivity scale (SCASS) with scores2 [22]. 2017;457:2530. It remains a prevalent global disease with two different treatment modalities of home-care desensitisation with the over-the-counter (OTC) desensitisers such as potassium, [28] reporting the immediate effect of 8% strontium acetate in alleviating clinical symptoms of DH with clinically and statistically significant (<0.001) measures relative to baseline [26]. YES Somewhat No 3 Report Deon Hines-0003, 2016. Researchers have investigated the clinical efficacy of popular propriety occluding dentifrices containing Pro-argin, strontium acetate, and FCPS formulations for treating DH and have found no adverse effects. PubMed 2009;22(Spec No. PubMed Central The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Innehller slipmedel med ltt polerande effekt p flckar samt fluor som minskar risken fr karies. It has stannous fluoride as an active ingredient. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Oral dentifrices were provided to the subject free of cost. Directions ClinicalTrial.gov: National Library of Medicine (US). The current study outcomes showed significant decrease in pain scores of air-blasts and water jet stimulated DH with FCPS based dentifrices compared to Pro-argin and 8% strontium acetate after two, four, and six weeks subsequently, as depicted in Tables 4 and 5. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth. Friedman Test was used to observe post-application change in treatment responses within the group for 6weeks. Participants were randomly allocated to four treatment arms and randomly assigned with OTC dentifrices having FCPS, Pro-argin, strontium acetate, and sodium fluoride (NaF) with an allocation ratio of 1:1:1:1. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste is an everyday toothpaste. Though all bioactive agents have a significant treatment effect in reducing DH, there is currently no consensus on the unequivocal efficacy of any product or bioactive agent used for managing the condition due to huge variations and heterogeneity in the conduct of clinical trials on DH [6]. CONCLUSION: The study results support the following conclusions: (1) Colgate Sensitive Pro-Relief toothpaste provides a significantly more reduction in dentin hypersensitivity than Sensodyne. Colgate Sensitive Pro Relief Multi Protection, offering all of the above benefits in one convenient formula. Helps restore natural whiteness of teeth. The sealed envelope contained details of unique subject numbers assigned individually in ascending order, group titles, and treatment codes and was placed in the box. Colgate Sensitive Pro Relief offers a solution that is clinically proven to relieve sensitivity pain. Tandkrmen remineraliserar tandemaljen fr att ge bttre motstnd mot syraattacker. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste delivers instant* and long-lasting sensitivity relief plus gum protection. It improves gum health and helps reduce factors that contribute to gum recession, a leading cause of tooth sensitivity. 2017;62(2):18691. Docimo et al. The Gum Health Physical is a new interactive digital tool you can use to quickly evaluate your patients in-office, and give them a personalized report they can use at home. Click & Collect. The findings have revealed that both statistically and clinically significant change in mean scores of DH was observed with Pro-argin and 8% strontium acetate with p<0.05 relative to baseline for immediate and sustained relief from DH using clinical parameters of SCASS and VAS. Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in J Dent. was used for statistical analysis. Moreover, FCPS as a new bioactive material revealed promising potency of sustainable management of DH in a previously conducted trial by Ashwini et al. J Clin Dent 20 (2009), special issue 123-130, 2. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. The Pro-Argin technology repairs sensitive areas of the teeth for instant* and long-lasting sensitivity pain relief. The statistician was also kept blinded. These then interact to form a complex with positive charge. Help Caregivers Understand Caries | Colgate Professional, compared to a leading brand of desensitizing toothpaste, Colgate Sensitive Pro Relief Repair and Prevent, Colgate Sensitive Pro Relief Enamel Repair, Colgate Sensitive Pro Relief Multi Protection. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. All rights reserved. Buy Colgate Sensitive Pro Relief and get the best deals at the lowest prices on eBay! However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. Another study by Hines et al. How does Colgate Sensitive Pro-Relief Repair & Prevent work? Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis. Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an 8-week clinical study. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. 2. Dent Health Curr Res. Am J Dent. Am J Dent. Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. 2020;99(5):51422. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. Cite this article. Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. All the treatment groups showed statistically significant improvement in DH with p<0.001 relative to baseline at all time points. Pak Oral Dent J. Was this answer helpful? Favaro Zeola L, Soares PV, Cunha-Cruz J. 2015;28(1):404. Contemp Clin Dent. J Oral Rehabil. Purchased in August 2019 at Coles for $5. Colgate Sensitive Pro-relief Instant Relief. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. 2019;88:103170. J Clin Dent. Douglas-de-Oliveira DW, Vitor GP, Silveira JO, Martins CC, Costa FO, Cota LOM. Table 4 demonstrates a comparison between treatment groups observing better clinical efficacy in managing DH on SCASS. 6 Ipsos, Romania Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2-week trial, 545 respondents, 2015. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Size: 75ml (Approx.) No side effects, apart from money not well spent. In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. Oral Care Products | Colgate Professional, Colgate Toothpaste - Dentists & Patients | Colgate Professional, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste, Instantly* relieves dentine hypersensitivity, Long-lasting relief from the pain of sensitive teeth, Helps strengthen gums and prevent gum recession, Recommended fluoride level for caries protection (1450ppm). 4 Hines D et al. Kp nu. A head-to-head comparative evaluation of these most effective bioactive agents, such as arginine and BAG-based desensitisers, was suggested by Martins et al. who examined FCPS and Pro-argin formulations in 2018. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily Manage cookies/Do not sell my data we use in the preference centre. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. While FCPS in BioMin F can be the best possible treatment option for long-term management of DH in the form of OTC dentifrices. Dentin hypersensitivity. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, et al. The Colgate Sensitive Pro Relief range features toothpastes that provide relief for sensitive teeth while addressing other common oral health concerns: Colgate Sensitive Pro Relief Repair and Prevent to protect against gingival recession. 0:00 / 0:30 Colgate Sensitive Pro-Relief Challenge Advert April 2012 178,990 views Mar 29, 2012 Take the Colgate Sensitive Pro-Relief Challenge to Show more 15 Dislike Share. Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml Holland G, Narhi M, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (4.201.70) followed by strontium acetate (4.651.87) followed by FCPS (5.101.88) one minute after application. Get the best deals for COLGATE Sensitive Pro Relief Complete Protection Toothpaste 110g. These fluorapatite crystals were less susceptible to acidic dissolution than hydroxyapatite crystals and thus were more desirable [13]. 2009; 20 (Spec Iss): 1722. Based on the synthesis of study results, we can conclude that Pro-argin in Colgate Sensitive Pro-relief and 8% strontium acetate in Sensodyne Rapid Action both are effective for pain relief in one minute after application in DH with better immediate treatment response of Pro-argin than strontium acetate. The benefits are backed by over a decade of clinical research, summarized as follows. The second null hypothesis was that mean scores for pain due to DH among different treatment groups for sustained relief remains the same, and it was considered to be rejected at a p value0.05. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. The maximum sampling time was 15min. Cunha-Cruz J, Wataha JC. Treatment difference between FCPS, Pro-argin, and 8% strontium acetate was not statistically significant with a p>0.05 for sustained pain relief in DH. Colgate Sensitive Pro Relief Enamel Repair to strengthen weakened enamel and prevent enamel loss. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. 3rd edition, Public Health England 2014. Privacy 2010;21(2):568. [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. Another . 1):8A-15A. J Dent Res. For children 6-12 years of age, once a week or less frequently. With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. Mantzourani M, Sharma D. Dentine sensitivity: past, present and future. The effectiveness of Colgate SENSITIVE INSTANT Relief toothpaste is built on its Pro-Argin technology with arginine and calcium from calcium carbonate. YYYY Colgate-Palmolive Company. Colgate Sensitive Instant Relief Repair & Prevent tandkrm ger dig kliniskt bevisad lngvarig lindring mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. All rights reserved. Colgate-Palmolive Company 2018. Colgate SENSITIVE INSTANT Relief tannkrem med Pro-Argin teknologi gir umiddelbar* og langvarig smertelindring av ising i tennene. Colgate Sensitive Instant* Relief Enamel Repair Toothpaste gives you clinically proven lasting relief** from sensitivity for 8 weeks when you use it twice a day. In addition, one-Way ANOVA with Post Hoc Tukey for pair-wise comparison was used to compare treatment groups computing percent change from baseline with formula (post-application mean scores-baseline mean scores/baseline mean scores). 2009;22:3A-7A. 1). Difference in effectiveness between strontium acetate and arginine-based toothpastes to relieve dentin hypersensitivity. Article Compared to stannous fluoride/sodium fluoride and novamin/sodium fluoride. 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. The impact of FCPS, Pro-argin, and strontium acetate-based treatments of DH on the oral health-related quality of life together with the difference in the effectiveness of treatments were assessed individually rather than in groups in the current six-week trial. Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. The prime focus of treatment nowadays is based on the exploration of novel materials to remineralise the exposed tubular endings and mimic and restore the structure of the dentin [11]. J Clin Dent 2009; 20 (Spec Iss): 17-22. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 2020;20(3):101460. Google Scholar. Grading of Recommendations, Assessment, Development and Evaluations. There is no problem with every day and prolonged use. Amsterdam: Elsevier; 2015. p. 4576. However, there is a substantial possibility that these fluoridated dentifrices can reduce DH. Anvnd tv gnger dagligen. Results of our study, together with the results of the previous studies, confirm the immediate clinical efficacy of Pro-argin for the relief of DH. No adverse events like gingival inflammation, bad taste, allergies, fluoride incompatibility, and dental or tongue stains were observed for all dentifrices. They reported more clinical efficacy with BioMin than Pro-argin reduction in air-blast stimulated DH on VAS after one month [39]. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. When you recommend Colgate Sensitive Pro Relief, you can help your dentin hypersensitivity patients to enjoy a pain-free life, confident in the knowledge that youre providing a highly effective, evidence-based solution. The makers of Colgate Sensitive Pro-Relief and its rival, Sensodyne Rapid Relief, have been dobbing each other into the health regulator over advertising claims that the toothpastes give users "instant" relief to pain from sensitive teeth. The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. Written informed consent was obtained with a signed agreement plan to visit for six weeks at interim efficacy intervals of day three, week two, week four, and week six. Colgate Sensitive Pro-Relief Enamel Repair contains Pro-Argin formula, helping to remineralise enamel, strengthen teeth against acid in food and drinks, plus instantly plugs channels to sensitive nerves. A study evaluating the efficacy of strontium acetate relative to arginine-based dentifrices was conducted by West et al. Nachar Sinus Rinse System, 4pcs Professional Baby Nasal Irrigator Portable Infant Nose Cleaner Quick Rinse Device All Natural Relief - BPA Free More Convenient. The total sample size was 140 participants, with thirty-five in each group. *with direct application and daily brushing. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. J Clin Dent. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . J Oral Sci. Vu Pham T, Anh Nguyen T. Clinical evaluation of the desensitizing efficacy of a paste containing 8% arginine and calcium carbonate. Dentifrices were removed carefully after one minute of undisturbed application by rinsing the air lightly with an air syringe, and the subject was asked to spit. Colgate uses need to categorize. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (3.052.17) followed by strontium acetate (3.751.97) followed by FCPS (5.301.83) one minute after application. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. For lsting relief, apply to a gentle toothbrush making sure to brush all . Identifier NCT 04249336. blokerer jeblikkeligt smerter fra isninger. A 3-day randomised clinical study investigating the efficacy of two toothpastes, designed to occlude dentine tubules, for the treatment of dentine hypersensitivity. The Sensitive Pro-Relief Multi-Protection toothpaste by Colgate thoroughly cleans your teeth, while providing you with relief from sensitive tooth pain. Trials. Colgate Sensitive Pro Relief can be applied directly to the affected area for almost instant relief. *with direct application and daily brushing. Hu et al. 75 ml. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. Dentine hypersensitivity. How to use They don't. Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. 1). Therefore, the current study outcomes were analysed by parametric and non-parametric statistical tests after assessing the normal distribution of data and equality of variances with Shapiro Wilk statistics. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. Internal report 2018, 5. Colgate Sensitive Pro-Relief Instant Relief Sensitive Toothpaste - 75ml More Images Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. The datasets analysed during the current study are available from the corresponding author on reasonable request. Explore the videos and articles found on this page to assist in better oral care. * For instant relief apply to the sensitive tooth with a figure tip and gently massage for one minute. These participants were randomized equally by the principal investigator into four entitled treatment arms using computer-generated random sequence numbers, and treatments were allocated randomly using sequentially numbered, opaque, sealed, and stapled envelopes (SNOSE). Colgate-Palmolive Company 2018. Table 6 presents the change in the mean scores on VAS against waterjet stimulus from baseline to subsequent efficacy interval within each treatment arm. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. YYYY Colgate-Palmolive Company. Colgate Sensitive PRO-Relief Provides clinically proven, everyday protection from painful sensitivity. In vitro analysis suggested that FCPS-based dentifrice enabled the slow and sustained release of fluoride contents, resulting in more stable fluorapatite crystals in saliva [14, 15]. Colgate Sensitive Pro Relief Instant Relief, Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. This trial was registered in an ICMJE approved registry at https://clinicaltrials.gov/) under protocol Identifier: NCT04249336 [19] following the CONSORT guidelines [20] for parallel-group randomized trials after approval from the Institutional Review Board of Dow University of Health Sciences with reference no. All authors read and approved the final manuscript. 2017;2017:2. Hence, the effectiveness of clinically available formulations of FCPS in OTC dentifrices needs further exploration for the permanent management of DH. Colgate Tandpasta Sensitive Instant Relief Whitening. 1 Nathoo et al. fluorides, arginine, strontium, and bioactive glasses (BAG) [4] and in-office application of bioactive formulations such as glutaraldehyde, resin-based bonding agents and restorative materials, amorphous calcium phosphate based-tooth mousse, and lasers in the dental clinics [5]. Lai HY, Lee S, Toh SW, Li Y, Mateo LR, Morrion BM, Zhang Y: The clinical efficacy of a new dentifrice with zinc on plaque and gingivitis. Written consent was obtained from all participants to participate in the six-week clinical trial. 2016;36(3):4403. Google Scholar. 2017;59(4):4618. It was found statistically significant relative to control on all clinical parameters of the SCASS and VAS.
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